منابع مشابه
Derivatives of Glucuronic Acid
The presence of glucuronic acid in the complex molecules of specific bacterial polysaccharides (1) has stimulated a study of certain derivatives of this important substance and its lactone, glucuron. These investigations have entailed the necessity of elaborating a satisfactory method for preparing both the acid and its lactone, and at the same time they have embraced a study of the comparative...
متن کاملO-Sulfated Derivatives of Glucuronic Acid
4-O-Substituted D-glucuronic acid derivatives were synthesized from D-glucose in order to study the regioselectivity of sulfation. Introduction Glycosaminoglycans, as heparin and heparan sulfate, interact with various proteins, and their binding properties are related to the glycosidic sequence and the number and position of sulfate groups. In our laboratory, we performed a variety of chemical ...
متن کاملStimulation of microsomal uridine diphosphate glucuronyltransferase by glucuronic acid derivatives.
The glucuronic acid adducts of 1-naphthol, 2-naphthol and 4-methylumbelliferone activate microsomal UDP-glucuronyltransferase (EC 2.4.1.17) when the enzyme is assayed with p-nitrophenol as aglycone. Phenyl glucuronide and oestriol 3beta-glucuronide also activate UDP-glucuronyltransferase. but to a lesser extent. Activation by glucuronides is not dependent on metal ions, but is blocked by prior ...
متن کاملMicroanalysis of Glucuronide Glucuronic Acid as Applied to /3-glucuronidase and Glucuronic Acid Studies*
In recent years, interest in the metabolism of glucuronic acid has grown. Contributions have ranged from studies of its biosynthesis and conjugation in surviving tissues and exper,imental animals to its utilization in man (l-lo). In all spheres, especially the latter, progress has been hampered by the lack of an analytical method by which glucuronides could be differentiated from free glucuroni...
متن کاملDerivatives of Glucuronic Acid I. the Preparation of Glucuronic Acid from Glucuron and a Comparison of Their Reducing Values by Walther F. Goebel and Frank H. Babers
The presence of glucuronic acid in the complex molecules of specific bacterial polysaccharides (1) has stimulated a study of certain derivatives of this important substance and its lactone, glucuron. These investigations have entailed the necessity of elaborating a satisfactory method for preparing both the acid and its lactone, and at the same time they have embraced a study of the comparative...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1938
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(18)74088-x